Clinical Research

Carotid Artery Trials

Carotid stent vs. endarterectomy in low risk, symptomatic patients – Randomized trial to study carotid stent vs. endarterectomy. (CREST Trial)

Carotid Stent Registries – Carotid stenting with embolic filters for high risk patients. Several trials using FDA approved devices.

* All carotid trials include embolic protection device

PFO Trials

PFO Closure Study – Randomized (1:1) 2 year clinical trial evaluating PFO Closure with the STARFlex™ Septal Closure Device to Best Medical Therapy (Aspirin and/or Warfarin) in patients with stroke or TIA. ( CLOSURE I Trial)

PFO Closure Registry – Patients suffering from at least two strokes with the most recent CVA occurring while therapeutic on an approved anticoagulant or antiplatelet may enroll in this 1 year registry and be closed using the STARFlex™ Septal Closure Device. (The CARS Clinical Registry)

Investigator-Initiated Trials

Response to Aspirin in Migraineurs - Determine the prevalence of aspirin resistance among migraineurs after receiving 325mg of aspirin therapy for at least 14 consecutive days. This is a clinic-based study that utilizes the VerifyNow aspirin assay technology. (RAM Trial)

Other Cardiac Trials

Left Atrial Appendage Closure for Atrial Fibrillation – Multi-center, randomized (2:1) study comparing the WATCHMAN Left Atrial Appendage System for Embolic Protection to long-term warfarin therapy, in AF patients eligible for warfarin therapy, a CHADs score of 1 or greater and meeting echocardiographic criteria . ( PROTECT AF Trial)

Percutaneous mitral valve repair for mitral insufficiency – Multi-center, randomized study of the Evalve Cardiovascular Valve Repair System in the treatment of mitral valve regurgitation. Phase II evaluation of the safety and effectiveness of an endovascular approach to treatment of mitral valve regurgitation using CVRS. Randomized to surgical repair. (EVEREST II Trial)

Percutaneous valve study - Non-randomized trial evaluating the safety of the Carillon implant in the coronary sinus/great coronary vein of subjects with functional mitral regurgitation. (COMPETENT Trial)

Medical Trials

ActiveBiotics – Randomized Evaluation of Short-term Rifalazil Treatment of Carotid Atherosclerosis and Intima Media Thickness. (RESTORE-IT Trial)

Peripheral Trials

Chronic Total Occlusions – Prospective registry design study of high frequency mechanical recanalization system to facilitate crossing of CTOs following failed standard guidewire techniques. (PATRIOT Trial)

Coronary Artery Trials

No current enrolling Coronary Artery trials.

Saphenous Vein Graft

No current enrolling SVG trials.

FOR MORE INFORMATION ON TRIALS OR TO ENROLL A PATIENT

Page the Research Coordinator at (206) 560-0889 or
Call the Cardiovascular Research Office at (206) 386-6191 or
Visit www.swedish.org (heart institute homepage)